How does COVID-19 affect the implementation of CORSIA?

This paper investigates the impacts of COVID-19 on the implementation of Carbon Offsetting and Reduction Scheme for International Aviation (CORSIA). By using the Automatic Dependent Surveillance-Broadcast (ADS-B) aviation data, the forecast methods of Gompertz and Logistic curves and four COVID-19 scenarios, we find the following results. First, the international aviation activities of developing countries are on the track of rapid growth, while the trends of developed countries are relatively slow or even close to saturation. Second, our results provide retrospective support for the decision of the ICAO Council to revise the implementation baseline of CORSIA. The adjustment of the baseline has saved countries considerable purchasing offsetting costs, especially for China, the United States, the United Arab Emirates, and the United Kingdom. Third, although the adjustment of the baseline can lower the economic pressure of the global aviation industry, CORSIA will still bring considerable financial burden to international aviation enterprises.

A Combination of Sorafenib, an Immune Checkpoint Inhibitor, TACE and Stereotactic Body Radiation Therapy versus Sorafenib and TACE in Advanced Hepatocellular Carcinoma Accompanied by Portal Vein Tumor Thrombus.

Background: This study compared the effectiveness of the combined administration of sorafenib, an immune checkpoint inhibitor, transcatheter arterial chemoembolization (TACE), and stereotactic body radiation therapy (SBRT) (SITS group) vs. sorafenib combined with TACE (ST group) in treating and downstaging advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). Methods: The present study included patients with advanced HCC and PVTT treated with one of the above combination therapies. The downstaging rate, objective response rate (ORR), progression-free survival (PFS), overall survival (OS), disease control rate (DCR), and adverse events (AEs) were assessed. Results: Sixty-two patients were analyzed. The ORR was elevated in the SITS group compared with the ST group (p = 0.036), but no differences were found in DCR (p = 0.067). The survival analysis revealed higher PFS (p = 0.015) and OS (p = 0.013) in the SITS group, with median PFS and OS times of 10.4 and 13.8 months, respectively. Ten patients displayed successful downstaging and underwent surgery in the SITS group, vs. none in the ST group. The prognosis was better in surgically treated patients compared with the non-surgery subgroup, based on PFS (p < 0.001) and OS (p = 0.003). Despite a markedly higher rate of AEs in the SITS group (p = 0.020), including two severe AEs, the SITS combination therapy had an acceptable safety profile. Conclusion: The SITS combination therapy yields higher PFS and OS than the combined administration of sorafenib and TACE in patients with advanced HCC and PVTT, especially as a downstaging strategy before surgery.

Combination of Sorafenib, Camrelizumab, Transcatheter Arterial Chemoembolization, and Stereotactic Body Radiation Therapy as a Novel Downstaging Strategy in Advanced Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Case Series Study.

BACKGROUND AND AIM: Although the treatment effect and availability of therapeutic options for advanced hepatocellular carcinoma (HCC) are limited, the downstaging strategy may improve patient prognosis. This study aimed to investigate the potential of combination therapy as a downstaging strategy for treating advanced HCC with portal vein tumor thrombus (PVTT). METHODS: This retrospective case series included patients having advanced HCC with PVTT, who received the combination therapy of sorafenib, camrelizumab, transcatheter arterial chemoembolization (TACE), and stereotactic body radiation therapy (SBRT) from January 2019 to December 2019 in Xiangya Hospital, Central South University. The downstaging rate, treatment responses, progression-free survival (PFS), overall survival (OS), disease control rate, and toxicities were evaluated. RESULTS: Of the 13 patients, HCC downstaging was achieved in 4 (33.3%) patients who later received hepatectomy. The overall response rate was 41.7%, and the disease control rate was 50.0%. The median PFS time was 15.7 months, with a 1-year PFS rate of 58.3%, whereas the median OS was not reached after 1 year (1-year OS, 83.3%). No severe adverse events or grade 3-4 adverse effect was observed in 12 of the 13 enrolled patients; therapy had to be discontinued in only one patient due to adverse events, who was excluded from the study. The most common adverse effect was fever (n = 4, 33.3%), followed by skin reaction (n = 3, 25%). CONCLUSION: A combination therapy comprising sorafenib, camrelizumab, TACE, and SBRT is an effective downstaging strategy for advanced HCC with PVTT and is associated with few adverse events.

Fabrication of submicron-diameter silica fibers using electric strip heater.

In nonlinear optical frequency conversion process, it is desirable to maximize the product of the intensity of pump laser and the interaction length in order to achieve maximum conversion efficiency. In this paper, long and unbroken submicron-diameter optical fibers with low optical loss about 0.1dB/cm were fabricated with a new drawing process by heating the conventional single mode fiber using a designed electric strip heater. Pumped by a 532 nm mode-locked pico-second laser, enhanced SRS phenomena can be observed in the submicron-diameter fibers with relative low pump power.

Index profiling of anisotropic graded-index planar waveguides from effective indices.

We present a method for recovering the refractive-index profile of an anisotropic graded-index waveguide from the effective indices by using a cubic spline interpolation function. The first and second derivatives of cubic splines are continuous to ensure a smooth index profile, which is consistent with practical graded-index distributions. A straightforward iteration with an exact dispersion equation to verify the interpolated profile makes this method easy and reliable for application. This approach is proved by numerical analysis of several typical index distributions and experimental examples showing that the refractive-index profiles in anisotropy can be reconstructed close to the exact profile. Waveguides with both more modes (more than four guiding modes) and fewer modes (two to four) can be universally profiled with good accuracy.

Explicit analysis of anisotropic planar waveguides by the analytical transfer-matrix method.

The propagation properties of light in anisotropic optical planar waveguides with different index distributions are investigated with the analytical transfer-matrix method. Dispersion equations are analytically deduced by the method in terms of different index profiles. It is shown by examples that this method exhibits good accuracy compared with numerical methods while still holding physical insight.